Severe Skin Rash and Liver Toxic Effects Caused By First-Line Anti-Tuberculosis Drugs: A Case Report

The adverse reactions of anti-tuberculosis drugs mainly include drug-induced liver injury, gastrointestinal reactions, and skin rash. Currently, the first-line anti-tuberculosis strategy in China includes the application of isoniazide, rifampicin, pyrazinamide, and ethambutol. Despite the high effectiveness, the serious adverse reactions caused by this strategy may cause a lot of patients discontinue the treatment [1]. The most common adverse reaction caused by the first-line anti-tuberculosis drugs is mild liver dysfunction [2], while severe liver toxic effects including liver failure or even death are very rare. The other adverse reactions caused by the first-line anti-tuberculosis drugs include rashes on the local or full body skin [3], of which maculopapule is the most common type.